Does Audirvana 3.5 bypass the settings in Mac Audio Midi Setup?

I use a Schiit Modi 3 connected to a 2018 Mac mini running Audirvana 3.5.20 (3550). Do the settings in Audio Midi Setup for the Modi 3 influence Audirvana at all or does Audirvana bypass these settings and take exclusive control of the Modi 3? Thanks.

All settings in Audio Midi setup are bypassed, except the speakers configuration of multichannel devices.

Thank you, Damien. I appreciate your product every time I listen to music.