I have the same problem if I add an app to the Applications folder or open an email only Mac ruining Catalina and Audirvana 3.5.28. I have included a copy of the debug report if this will help anyone to discover a solution!
Audirvana Mac Version 3.5.28 (3558)
macOS 10.15.1 with 65536MB RAM
Registered to JohnGregory Turner
SIGNAL PROCESSING:
Polarity Inversion:
Globally: OFF
Per track: ON
Effects plugins ACTIVE in offline mode
No plugin active
UPSAMPLING:
SoX not in use
SoX filter parameters
Bandwidth at 0dB = 99.5
Filter max length = 30000
Anti-aliasing = 100
Phase = 66
AUDIO VOLUME:
Max allowed volume: 100
Replay Gain: None
SW volume control: ON
LIBRARY SETTINGS:
Sync list: 1 folders
AUTO: /Volumes/Mystery Box/
iTunes/Music library synchronization: last synchronized on Wed Nov 13 06:06:04 2019
Library database path: /Users/johngregoryturner/Library/Application Support/Audirvana/AudirvanaPlusDatabaseV2.sqlite
ACTIVE STREAMING SERVICES
=================== AUDIO DEVICE ========================
CoreAudio audio path, buffer I/O frame size: 512
Max. memory for audio buffers: 62464MB
Local Audio Engine:
Exclusive access: Enabled
Integer mode: Enabled
Preferred device:
Built-in Output
Model UID:
UID:
Active Sample Rate: 48kHz
Hog Mode is off
Bridge settings:
Sample rate limitation: none
Sample rate switching latency: none
Limit bitdepth to 24bit: OFF
Mute during sample rate change: OFF
Selected device:
Local audio device
ID 0xf2 Built-in Output Manufacturer:Apple Inc.
Model UID:AppleHDA:16 UID:AppleHDAEngineOutput:1F,3,0,1,1:0
3 available sample rates up to 96000Hz
44100
48000
96000
Audio buffer frame size : 15 to 4096 frames
Current I/O buffer frame size : 512
Volume Control
Physical: No
Virtual: Yes
MQA capability
Auto-detect MQA devices: No
Not a MQA device, user set to not MQA
DSD capability: Unhandled
Device audio channels
Preferred stereo channels L:1 R:2
Channel bitmap: Ox3, layout:
Channel 0 mapped to 0
Channel 1 mapped to 1
Audio channels in use
Number of channels: 2
Use as stereo device only: No
Simple stereo device: Yes
1 output streams:
Number of active channels: 2, in 1 stream(s)
Channel #0 :Stream 0 channel 0
Channel #1 :Stream 0 channel 1
Stream ID 0xf3 2 channels starting at 1
3 virtual formats:
2 ch Mixable linear PCM Interleaved 32 little endian Signed Float 96kHz
2 ch Mixable linear PCM Interleaved 32 little endian Signed Float 48kHz
2 ch Mixable linear PCM Interleaved 32 little endian Signed Float 44.1kHz
3 physical formats
2 ch Mixable linear PCM Interleaved 24 little endian Signed Integer aligned low in 32bit 96kHz
2 ch Mixable linear PCM Interleaved 24 little endian Signed Integer aligned low in 32bit 48kHz
2 ch Mixable linear PCM Interleaved 24 little endian Signed Integer aligned low in 32bit 44.1kHz
Local devices found : 3
Device #0: ID 0xf2 Built-in Output Manufacturer: Apple Inc. Model UID: AppleHDA:16 UID: AppleHDAEngineOutput:1F,3,0,1,1:0
Device #1: ID 0x102 MMAudio Device Manufacturer: MMAudio Device contributors Model UID: MMAudioDeviceModelUID UID: MMAudioDevice
Device #2: ID 0x107 MMAudio Device (UI Sounds) Manufacturer: MMAudio Device contributors Model UID: MMAudioDeviceModelUID_UISounds UID: MMAudioDevice_UISounds
UPnP devices found : 1
Device #0: ID 0x0 TMM RVU Client MediaRenderer UID: uuid:MediaRenderer-FC_52_8D_CC_59_B0 Location: http://169.254.9.165:63445/upnp/xml/devices/MediaRenderer1.xml